What significant contribution did Susan B. Anthony make?

Susan B. Anthony is most renowned for her tireless work in the fight for women's rights and suffrage. She played a pivotal role in the women's suffrage movement in the United States during the 19th century. Her advocacy for women’s right to vote was groundbreaking, as she organized campaigns, delivered speeches, and worked alongside other reformers, including Elizabeth Cady Stanton.

Anthony’s commitment to achieving voting rights for women was a significant aspect of her legacy, highlighted by her efforts to lead initiatives that challenged societal norms and legal barriers against women’s participation in politics. The culmination of her efforts can be seen in her involvement with the National American Woman Suffrage Association, which sought to secure the right to vote for women across the nation.

While the other options refer to important social issues, they do not directly capture the essence of Anthony's primary focus. Her lifelong dedication to women's suffrage distinguishes her as a key figure in the movement for gender equality and civil rights in America.